Högskolan i Skövde

Preschool children, when diagnosed with Autism Spectrum Disorder (ASD), often ex- perience a long and painful journey on their way to self-advocacy. Access to standard of care is poor, with long waiting times and the feeling of stigmatization in many social set- tings. Early interventions in ASD have been found to deliver promising results, but have a high cost for all stakeholders. Some recent studies have suggested that digital biomarkers (e.g., eye gaze), tracked using affordable wearable devices such as smartphones or tablets, could play a role in identifying children with special needs. In this paper, we discuss the possibility of supporting neurodiverse children with technologies based on digital biomark- ers which can help to a) monitor the performance of children diagnosed with ASD and b) predict those who would benefit most from early interventions. We describe an ongoing feasibility study that uses the “DREAM dataset”, stemming from a clinical study with 61 pre-school children diagnosed with ASD, to identify digital biomarkers informative for the child’s progression on tasks such as imitation of gestures. We describe our vision of a tool that will use these prediction models and that ASD pre-schoolers could use to train certain social skills at home. Our discussion includes the settings in which this usage could be embedded. 

Background/objectives

To provide age- and sex-specific percentile curves of serum 25-hydroxyvitamin D (25(OH)D) by determinants from 3-<15 year-old European children, and to analyse how modifiable determinants influence 25(OH)D.

Subjects/methods

Serum samples were collected from children of eight European countries participating in the multicenter IDEFICS/I.Family cohort studies. Serum 25(OH)D concentrations were analysed in a central lab by a chemiluminescence assay and the values from 2171 children (N = 3606 measurements) were used to estimate percentile curves using the generalized additive model for location, scale and shape. The association of 25(OH)D with time spent outdoors was investigated considering sex, age, country, parental education, BMI z score, UV radiation, and dietary vitamin D in regressions models.

Results

The age- and sex-specific 5th and 95th percentiles of 25(OH)D ranged from 16.5 to 73.3 and 20.8 to 79.3 nmol/l in girls and boys, respectively. A total of 63% had deficient (<50 nmol/l), 33% insufficient (50-<75 nmol/l) and 3% sufficient (≥75 nmol/l) levels. 25(OH)D increased with increasing UV radiation, time spent outdoors, and vitamin D intake and slightly decreased with increasing BMI z score and age. The odds ratio (OR) for a non-deficient 25(OH)D status (reference category: deficient status) by one additional hour spent outdoors was 1.21, 95% CI [1.12–1.31], i.e., children who spent one more hour per day outdoors than other children had a 21% higher chance of a non-deficient than a deficient status.

Conclusion

A majority of children suffer from deficient 25(OH)D. UV radiation, outdoor time, and dietary vitamin D are important determinants of 25(OH)D.